American Medical Technologist (AMT) Practice Exam 2025 – All-in-One Resource to Guarantee Exam Success!

The correct answer is based on the best practices for preparing blood smears from EDTA (ethylenediaminetetraacetic acid) specimens. Blood smears should ideally be prepared within 1 hour of collection. This time frame is critical because blood cells, particularly white blood cells, begin to change morphologically and can begin to lyse if the blood sample is not processed within this period. The preservation of cell morphology is essential for accurate analysis, especially in hematological assessments.

If blood smears are prepared beyond this time frame, such as after 2 hours or 4 hours, there is a greater risk of altered cell characteristics due to the prolonged exposure to anticoagulants and the environment. This can lead to misinterpretation of the blood smear during microscopic examination. Preparing the blood smear quickly helps ensure that the sample reflects the patient's current blood cell status accurately, which is crucial for diagnostics and subsequent treatment decisions.